Ohio State vs Indiana Odds, Lines and Spread

Ryan Day walking

Ryan Day’s Buckeyes return to the field after their Week 11 game was cancelled. (Photo by Adam Lacy/Icon Sportswire)

  • #3 Ohio State is a 20.5-point favorite over #9 Indiana on Saturday, November 21st (Noon EST)
  • The Buckeyes have won nine straight games over top-10 ranked Big 10 opponents
  • See below for analysis, odds and a betting prediction

#9 Indiana (4-0) visits #3 Ohio State (3-0) on Saturday (Noon EST) in the biggest game on the Week 12 college football slate.

Both teams enter play undefeated, and despite their close proximity in the AP Top-25 rankings, oddsmakers are not expecting a close contest.

#9 Indiana vs #3 Ohio State Week 12 Odds

Team Spread Moneyline Total
Indiana Hoosiers +20.5 (-110) +680 Over 66.5 (-106)
Ohio State Buckeyes -20.5 (-110) -1200 Under 66.5 (-114)

Odds taken Nov. 18th at FanDuel

The Buckeyes are a massive 20.5-point home favorite in a game that features a total of 66.5. Ohio State’s Week 11 game versus Maryland was cancelled due to COVID, while Indiana is fresh off a 24-0 victory over Michigan State.

2021 CFP National Championship Odds Tracker

Hoosiers Chasing History

In addition to its blowout win over the Spartans, the Hoosiers also have victories over Rutgers, Michigan and Penn State. If they’re able to upset Ohio State, Indiana would have a clear path to the Big Ten title game, and could become the first champion to beat the Buckeyes, Nittany Lions, Wolverines and Spartans in the same season.

Last week’s convincing win over MSU was the program’s best defensive performance of the season, as they limited the Spartans to 191 total yards and nine first downs.

QB Michael Penix Jr. turned in his second straight 300-yard day, completing 65.8% of his passes and racking up two scores. Ty Fryfogle hauled in both touchdowns, and posted a career-best 11 catches for 200 yards, which was good enough to win Big 10 offensive player of the week honors.

The Hoosiers rank second in the Big Ten East division in points per game (33.8) and first in points allowed (19.3). As good as that looks on paper, it should be noted that each of their first four opponents have recorded 1 win or less so far, and none have a point differential better than -7.5.

Buckeyes are Beasts

Ohio State on the other hand, are averaging 46.3 points per game and have won all three of its games by at least 13 points. The Buckeyes are led by future Sunday star Justin Fields, who is among the favorites to win the Heisman this season.

The Junior QB leads the nation in completion percentage (86.7%), has an 11-0 TD-to-INT rate, and an FBS-best 96.4 QBR.

He’s 16-1 as a starter and averages 3.76 total touchdowns per outing.

Master Teague paces the rushing attack averaging 4.5 yards per carry and 1.33 TD per contest, while Chris Olave is one of the best wideouts in all of college football.

Ohio State’s defense meanwhile, is no joke. They’ve allowed just four touchdowns prior to garbage time this season, while averaging 1.7 takeaways and 3 sacks per game.

The Verdict

The Buckeyes have won 25 straight meetings in this series, and haven’t lost to the Hoosiers since 1988. Ohio State has also won nine straight games versus top-10 ranked Big 10 opponents, and we should expect another easy victory in this matchup.

Indiana’s wins may look impressive on paper, but the truth is each of its opponents is in the midst of a miserable season. They’ve yet to face a team ranked inside the top-70 by ESPN’s FPI, while the Buckeyes check in at #3.

The one silver lining for the Hoosiers, and potential Indiana backers, is that Ohio State has left the backdoor open all season. They’ve taken their foot of the gas in the 4th quarter each time out, and if they do so again, Indiana is more than capable of putting up enough points late to cover.

Pick: Indiana Hoosiers +20.5 (-110)

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Chris Amberley

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