New York Yankees starting pitcher Gerrit Cole throws during the second inning in Game 5 of a baseball American League Division Series against the Tampa Bay Rays, Friday, Oct. 9, 2020, in San Diego. (AP Photo/Gregory Bull)
- The 2021 MLB season starts on Thursday, April 1, at 1:05 pm ET
- All 30 teams will take the field on Opening Day, barring postponements
- See the odds for each of the 15 games on the slate
This Thursday, April 1st, marks Opening Day of the 2021 MLB season. All 30 teams are in action starting with the Toronto Blue Jays vs New York Yankees at 1:05 pm ET in the Bronx.
The day concludes with a trio of west-coast games circa 10:00 pm ET: Chicago White Sox vs LA Angels, Houston Astros vs Oakland Athletics, and San Francisco Giants vs Seattle Mariners.
Early odds have been released for almost every game on the slate.
You can bet the odds below at BetMGM
MLB Opening Day Odds
|Matchup||Odds at BetMGM|
|Toronto Blue Jays||+140|
|New York Yankees||-175|
|Boston Red Sox||-200|
|San Diego Padres||-227|
|St Louis Cardinals||-175|
|Kansas City Royals||-120|
|Tampa Bay Rays||-175|
|New York Mets||-120|
|Chicago White Sox||TBD|
|San Francisco Giants||TBD|
Odds as of March 29.
The Dodgers Are the Biggest Favorite
Up against a Colorado team that just traded franchise cornerstone Nolan Arenado, the reigning World Series champions are -303 favorites in their opener. The Dodgers also have, by far, the highest 2021 MLB win total.
The Opening Day start will go to the legend himself Clayton Kershaw.
Colorado will counter with German Marquez, who posted a 5.68 ERA at Coors Field last year, continuing his career-long struggles at home.
2021 World Series Odds Tracker
The Padres and Cubs Are the Biggest Home Favorites
The San Diego Padres and Chicago Cubs are both listed as -227 home favorites in their openers. For the Cubs, it’s all about the opponent. The Pittsburgh Pirates are projected to be the single-worst team in the MLB, for the second straight year. They are the lone team that hasn’t announced an Opening Day starter. Mitch Keller is probably their best option, and he’s still technically a rookie.
The Padres’ opponent, the Arizona Diamondbacks, aren’t expected to challenge for the World Series, but they are only two seasons removed from an 85-win campaign. The lopsided odds in this one are almost entirely thanks to the fervor around the Friars. One of their prized offseason acquisitions, Yu Darvish, will get the nod in the opener. He finished second in Cy Young voting last year and will have the MLB’s third-best offense from 2020 backing him up.
Track all the Opening Day odds movement on SBD’s baseball odds page.
This article contains links to external sports betting services. SBD may receive advertising revenue from these links, however editorial has hand-picked each individual link based on relevance to the article, without influence on the coverage.
Sascha was a hockey player in his youth, a lawyer in his capricious mid-20s, and has now been an assigning editor, writer, and lead oddsmaker for SBD for over five years. He covers everything you can possibly put odds on, but specializes in football, baseball, hockey, and basketball.