Opening Odds for All MLB Opening Day Games

Gerrit Cole pitching

New York Yankees starting pitcher Gerrit Cole throws during the second inning in Game 5 of a baseball American League Division Series against the Tampa Bay Rays, Friday, Oct. 9, 2020, in San Diego. (AP Photo/Gregory Bull)

  • The 2021 MLB season starts on Thursday, April 1, at 1:05 pm ET
  • All 30 teams will take the field on Opening Day, barring postponements
  • See the odds for each of the 15 games on the slate

This Thursday, April 1st, marks Opening Day of the 2021 MLB season. All 30 teams are in action starting with the Toronto Blue Jays vs New York Yankees at 1:05 pm ET in the Bronx.

The day concludes with a trio of west-coast games circa 10:00 pm ET: Chicago White Sox vs LA Angels, Houston Astros vs Oakland Athletics, and San Francisco Giants vs Seattle Mariners.

Early odds have been released for almost every game on the slate.


You can bet the odds below at BetMGM

MLB Opening Day Odds

Matchup Odds at BetMGM
Toronto Blue Jays +140
New York Yankees -175
Matchup Odds
Cleveland -154
Detroit Tigers +130
Matchup Odds
Baltimore Orioles +160
Boston Red Sox -200
Matchup Odds
Minnesota Twins -149
Milwaukee Brewers +120
Matchup Odds
Pittsburgh Pirates +180
Chicago Cubs -227
Matchup Odds
Atlanta Braves -115
Philadelphia Phillies -115
Matchup Odds
Arizona Diamondbacks +180
San Diego Padres -227
Matchup Odds
LA Dodgers -303
Colorado Rockies +235
Matchup Odds
St Louis Cardinals -175
Cincinnati Reds +140
Matchup Odds
Texas Rangers +100
Kansas City Royals -120
Matchup Odds
Tampa Bay Rays -175
Miami Marlins +140
Matchup Odds
New York Mets -120
Washington Nationals -110
Matchup Odds
Chicago White Sox TBD
LA Angels TBD
Matchup Odds
Houston Astros +100
Oakland Athletics -120
Matchup Odds
San Francisco Giants TBD
Seattle Mariners TBD

Odds as of March 29.

The Dodgers Are the Biggest Favorite

Up against a Colorado team that just traded franchise cornerstone Nolan Arenado, the reigning World Series champions are -303 favorites in their opener. The Dodgers also have, by far, the highest 2021 MLB win total.

The Opening Day start will go to the legend himself Clayton Kershaw.

Colorado will counter with German Marquez, who posted a 5.68 ERA at Coors Field last year, continuing his career-long struggles at home.

2021 World Series Odds Tracker

The Padres and Cubs Are the Biggest Home Favorites

The San Diego Padres and Chicago Cubs are both listed as -227 home favorites in their openers. For the Cubs, itโ€™s all about the opponent. The Pittsburgh Pirates are projected to be the single-worst team in the MLB, for the second straight year. They are the lone team that hasnโ€™t announced an Opening Day starter. Mitch Keller is probably their best option, and heโ€™s still technically a rookie.

The Padresโ€™ opponent, the Arizona Diamondbacks, arenโ€™t expected to challenge for the World Series, but they are only two seasons removed from an 85-win campaign. The lopsided odds in this one are almost entirely thanks to the fervor around the Friars. One of their prized offseason acquisitions, Yu Darvish, will get the nod in the opener. He finished second in Cy Young voting last year and will have the MLBโ€™s third-best offense from 2020 backing him up.

Track all the Opening Day odds movement on SBDโ€™s baseball odds page.

This article contains links to external sports betting services. SBD may receive advertising revenue from these links, however editorial has hand-picked each individual link based on relevance to the article, without influence on the coverage.

Author Image

Sascha Paruk

NFL NBA MLB NHL NCAAF NCAAB Politics Tennis MMA Sportsbooks Gambling Lead Oddsmaker & Editor

NFL NBA MLB NHL NCAAF NCAAB Politics Tennis MMA Sportsbooks Gambling